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TitleMutational Analysis of Encephalitozoon cuniculi mRNA Cap (Guanine-N7) Methyltransferase, Structure of the Enzyme Bound to Sinefungin, and Evidence That Cap Methyltransferase Is the Target of Sinefungin's Antifungal Activity
Journal, issue, pagesJ. Biol. Chem., Vol. 281, Page 35904-35913, Year 2006
Publish dateJul 27, 2006 (structure data deposition date)
AuthorsZheng, S. / Hausmann, S. / Liu, Q. / Ghosh, A. / Schwer, B. / Lima, C.D. / Shuman, S.
External linksJ. Biol. Chem. / PubMed:16971388
MethodsX-ray diffraction
Resolution2.6 Å
Structure data

PDB-2hv9:
Encephalitozoon cuniculi mRNA Cap (Guanine-N7) Methyltransferase in complex with sinefungin
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

Chemicals

ChemComp-SFG:
SINEFUNGIN

ChemComp-HOH:
WATER

Source
  • encephalitozoon cuniculi (fungus)
KeywordsTRANSFERASE / MRNA / CAP / METHYLTRANSFERASE / INHIBITOR

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