+Search query
-Structure paper
Title | Discovery of potent, efficacious, and orally bioavailable inhibitors of blood coagulation factor Xa with neutral P1 moieties. |
---|---|
Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 16, Page 5584-5589, Year 2006 |
Publish date | Feb 10, 2006 (structure data deposition date) |
Authors | Pinto, D.J. / Galemmo, R.A. / Quan, M.L. / Orwat, M.J. / Clark, C. / Li, R. / Wells, B. / Woerner, F. / Alexander, R.S. / Rossi, K.A. ...Pinto, D.J. / Galemmo, R.A. / Quan, M.L. / Orwat, M.J. / Clark, C. / Li, R. / Wells, B. / Woerner, F. / Alexander, R.S. / Rossi, K.A. / Smallwood, A. / Wong, P.C. / Luettgen, J.M. / Rendina, A.R. / Knabb, R.M. / He, K. / Wexler, R.R. / Lam, P.Y. |
External links | Bioorg. Med. Chem. Lett. / PubMed:16963264 |
Methods | X-ray diffraction |
Resolution | 2.1 Å |
Structure data | PDB-2g00: |
Chemicals | ChemComp-4QC: |
Source |
|
Keywords | HYDROLASE / GLYCOPROTEIN / SERINE PROTEASE / PLASMA / BLOOD COAGULATION FACTOR / PROTEIN INHIBITOR COMPLEX / CALCIUM-BINDING |