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TitleMitogen-activated protein kinases interacting kinases are autoinhibited by a reprogrammed activation segment.
Journal, issue, pagesEmbo J., Vol. 25, Page 4020-4032, Year 2006
Publish dateAug 1, 2006 (structure data deposition date)
AuthorsJauch, R. / Cho, M.K. / Netter, C. / Schreiter, K. / Aicher, B. / Zweckstetter, M. / Wahl, M.C.
External linksEmbo J. / PubMed:16917500
MethodsX-ray diffraction
Resolution2.5 - 2.71 Å
Structure data

PDB-2hw6:
Crystal structure of Mnk1 catalytic domain
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

PDB-2hw7:
Crystal Structure of Mnk2-D228G in complex with Staurosporine
Method: X-RAY DIFFRACTION / Resolution: 2.71 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

ChemComp-ZN:
Unknown entry

ChemComp-STU:
STAUROSPORINE / anticancer, antifungal, antibiotic, alkaloid*YM

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / protein kinase / drug design / mnk1 / phosphorylation / protein kinases / drug / inhibitor

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