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TitleCrystal structure of anti-configuration of indomethacin and leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase complex reveals the structural basis of broad spectrum indomethacin efficacy
Journal, issue, pagesJ. Biochem. (Tokyo), Vol. 140, Page 457-466, Year 2006
Publish dateApr 20, 2006 (structure data deposition date)
AuthorsHori, T. / Ishijima, J. / Yokomizo, T. / Ago, H. / Shimizu, T. / Miyano, M.
External linksJ. Biochem. (Tokyo) / PubMed:16916844
MethodsX-ray diffraction
Resolution2 Å
Structure data

PDB-2dm6:
Crystal structure of anti-configuration of indomethacin and leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase complex
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-NAP:
NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE

ChemComp-IMN:
INDOMETHACIN / medication, antiinflammatory*YM

ChemComp-TAM:
TRIS(HYDROXYETHYL)AMINOMETHANE / pH buffer*YM

ChemComp-HOH:
WATER

Source
  • cavia porcellus (domestic guinea pig)
KeywordsOXIDOREDUCTASE / NAD(P)-binding Rossmann-fold domains / RIKEN Structural Genomics/Proteomics Initiative / RSGI / Structural Genomics

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