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Structure paper

TitleCrystal structures of a multidrug transporter reveal a functionally rotating mechanism
Journal, issue, pagesNature, Vol. 443, Page 173-179, Year 2006
Publish dateMar 23, 2006 (structure data deposition date)
AuthorsMurakami, S. / Nakashima, R. / Yamashita, E. / Matsumoto, T. / Yamaguchi, A.
External linksNature / PubMed:16915237
MethodsX-ray diffraction
Resolution2.8 - 3.3 Å
Structure data

PDB-2dhh:
Crystal structure of a multidrug transporter reveal a functionally rotating mechanism
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

PDB-2dr6:
Crystal structure of a multidrug transporter reveal a functionally rotating mechanism
Method: X-RAY DIFFRACTION / Resolution: 3.3 Å

PDB-2drd:
Crystal structure of a multidrug transporter reveal a functionally rotating mechanism
Method: X-RAY DIFFRACTION / Resolution: 3.1 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-DM2:
DOXORUBICIN / medication, chemotherapy*YM

ChemComp-MIY:
(4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2- / medication, antibiotic*YM

Source
  • escherichia coli (E. coli)
KeywordsMEMBRANE PROTEIN / membrane transporter / multidrug efflux / drug resistance / transporter / exporter / antiporter

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