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TitleStructural basis for the exceptional in vivo efficacy of bisphosphonate drugs.
Journal, issue, pagesChemmedchem, Vol. 1, Page 267-273, Year 2006
Publish dateDec 1, 2005 (structure data deposition date)
AuthorsRondeau, J.M. / Bitsch, F. / Bourgier, E. / Geiser, M. / Hemmig, R. / Kroemer, M. / Lehmann, S. / Ramage, P. / Rieffel, S. / Strauss, A. ...Rondeau, J.M. / Bitsch, F. / Bourgier, E. / Geiser, M. / Hemmig, R. / Kroemer, M. / Lehmann, S. / Ramage, P. / Rieffel, S. / Strauss, A. / Green, J.R. / Jahnke, W.
External linksChemmedchem / PubMed:16892359
MethodsX-ray diffraction
Resolution1.94 - 2.6 Å
Structure data

PDB-2f7m:
Crystal Structure of Unliganded Human FPPS
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-2f89:
Crystal structure of human FPPS in complex with pamidronate
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

PDB-2f8c:
Crystal structure of FPPS in complex with Zoledronate
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-2f8z:
Crystal structure of human FPPS in complex with zoledronate and isopentenyl diphosphate
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

PDB-2f92:
Crystal structure of human FPPS in complex with alendronate
Method: X-RAY DIFFRACTION / Resolution: 2.15 Å

PDB-2f94:
Crystal structure of human FPPS in complex with ibandronate
Method: X-RAY DIFFRACTION / Resolution: 1.94 Å

PDB-2f9k:
Crystal structure of human FPPS in complex with Zoledronate and Zn2+
Method: X-RAY DIFFRACTION / Resolution: 2.06 Å

Chemicals

ChemComp-PO4:
PHOSPHATE ION

ChemComp-HOH:
WATER

ChemComp-MN:
Unknown entry

ChemComp-210:
PAMIDRONATE

ChemComp-MG:
Unknown entry

ChemComp-ZOL:
ZOLEDRONIC ACID / medication*YM

ChemComp-IPE:
3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE

ChemComp-ZN:
Unknown entry

ChemComp-AHD:
4-AMINO-1-HYDROXYBUTANE-1,1-DIYLDIPHOSPHONATE / medication*YM

ChemComp-BFQ:
IBANDRONATE / medication*YM

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / TRANSFERASE; ISOPRENE BIOSYNTHESIS; CHOLESTEROL BIOSYNTHESIS / MEVALONATE PATHWAY; ISOPRENE BIOSYNTHESIS; CHOLESTEROL BIOSYNTHESIS; BISPHOSPHONATE INHIBITOR / Mevalonate pathway / ; isoprene biosynthesis; cholesterol biosynthesis; bisphosphonate inhibitor

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