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Structure paper

TitleEndogenous phosphatidylcholine and a long spacer ligand stabilize the lipid-binding groove of CD1b.
Journal, issue, pagesEmbo J., Vol. 25, Page 3684-3692, Year 2006
Publish dateMay 18, 2006 (structure data deposition date)
AuthorsGarcia-Alles, L.F. / Versluis, K. / Maveyraud, L. / Vallina, A.T. / Sansano, S. / Bello, N.F. / Gober, H.J. / Guillet, V. / de la Salle, H. / Puzo, G. ...Garcia-Alles, L.F. / Versluis, K. / Maveyraud, L. / Vallina, A.T. / Sansano, S. / Bello, N.F. / Gober, H.J. / Guillet, V. / de la Salle, H. / Puzo, G. / Mori, L. / Heck, A.J. / De Libero, G. / Mourey, L.
External linksEmbo J. / PubMed:16874306
MethodsX-ray diffraction
Resolution1.8 Å
Structure data

PDB-2h26:
human CD1b in complex with endogenous phosphatidylcholine and spacer
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

Chemicals

ChemComp-6PL:
(4S,7R)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSAN-1-AMINIUM 4-OXIDE / phospholipid*YM

ChemComp-6UL:
TETRACOSYL PALMITATE

ChemComp-GOL:
GLYCEROL

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / LIPID / endogenous ligand / phosphatidylcholine / MHC / ANTIGEN PRESENTATION / GLYCOPROTEIN

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