+Search query
-Structure paper
Title | Structure-based design and synthesis of macroheterocyclic peptidomimetic inhibitors of the aspartic protease beta-site amyloid precursor protein cleaving enzyme (BACE). |
---|---|
Journal, issue, pages | J. Med. Chem., Vol. 49, Page 4544-4567, Year 2006 |
Publish date | Nov 21, 2005 (structure data deposition date) |
Authors | Hanessian, S. / Yang, G. / Rondeau, J.-M. / Neumann, U. / Betschart, C. / Tintelnot-Blomley, M. |
External links | J. Med. Chem. / PubMed:16854060 |
Methods | X-ray diffraction |
Resolution | 2.11 - 2.3 Å |
Structure data | PDB-2f3e: PDB-2f3f: |
Chemicals | ChemComp-AXQ: ChemComp-HOH: ChemComp-AXF: |
Source |
|
Keywords | HYDROLASE / BETA-SECRETASE / MEMAPSIN2 / ALZHEIMER'S DISEASE / ASPARTIC PROTEASE / MACROCYCLIC PEPTIDOMIMETIC INHIBITOR |