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TitleHoogsteen base pair formation promotes synthesis opposite the 1,N(6)-ethenodeoxyadenosine lesion by human DNA polymerase iota.
Journal, issue, pagesNat. Struct. Mol. Biol., Vol. 13, Page 619-625, Year 2006
Publish dateMay 12, 2006 (structure data deposition date)
AuthorsNair, D.T. / Johnson, R.E. / Prakash, L. / Prakash, S. / Aggarwal, A.K.
External linksNat. Struct. Mol. Biol. / PubMed:16819516
MethodsX-ray diffraction
Resolution2.3 Å
Structure data

PDB-2dpi:
Ternary complex of hPoli with DNA and dCTP
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-2dpj:
structure of hPoli with DNA and dTTP
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-DCP:
2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE

ChemComp-HOH:
WATER

ChemComp-TTP:
THYMIDINE-5'-TRIPHOSPHATE

Source
  • homo sapiens (human)
KeywordsTRANSFERASE/DNA / DNA dependent DNA Polymerase / ethenodA adduct / lesion bypass / TRANSFERASE-DNA COMPLEX / dTTP

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