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Structure paper

TitleCellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2).
Journal, issue, pagesProc. Natl. Acad. Sci. Usa, Vol. 103, Page 9814-9819, Year 2006
Publish dateFeb 14, 2006 (structure data deposition date)
AuthorsMcDonough, M.A. / Li, V. / Flashman, E. / Chowdhury, R. / Mohr, C. / Lienard, B.M. / Zondlo, J. / Oldham, N.J. / Clifton, I.J. / Lewis, J. ...McDonough, M.A. / Li, V. / Flashman, E. / Chowdhury, R. / Mohr, C. / Lienard, B.M. / Zondlo, J. / Oldham, N.J. / Clifton, I.J. / Lewis, J. / McNeill, L.A. / Kurzeja, R.J. / Hewitson, K.S. / Yang, E. / Jordan, S. / Syed, R.S. / Schofield, C.J.
External linksProc. Natl. Acad. Sci. Usa / PubMed:16782814
MethodsX-ray diffraction
Resolution1.7 - 2.2 Å
Structure data

PDB-2g19:
Cellular Oxygen Sensing: Crystal Structure of Hypoxia-Inducible Factor Prolyl Hydroxylase (PHD2)
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

PDB-2g1m:
Cellular Oxygen Sensing: Crystal Structure of Hypoxia-Inducible Factor Prolyl Hydroxylase (PHD2)
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

Chemicals

ChemComp-FE2:
Unknown entry

ChemComp-4HG:
N-[(4-HYDROXY-8-IODOISOQUINOLIN-3-YL)CARBONYL]GLYCINE

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE / PHD2 / HIF / DSBH / OXYGENASE / TRANSCRIPTION / HYPOXIA / 2-OXOGLUTARATE / PROLYL HYDROXYLASE / HYDROXYLASE / EGLN / HPH / ELGN / SM-20 / TRANSCRIPTION ACTIVATOR / INHIBITOR

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