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TitleBACE-1 inhibition by a series of psi[CH2NH] reduced amide isosteres
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 16, Page 3635-3638, Year 2006
Publish dateAug 16, 2007 (structure data deposition date)
AuthorsCoburn, C.A. / Stachel, S.J. / Jones, K.G. / Steele, T.G. / Rush, D.M. / DiMuzio, J. / Pietrak, B.L. / Lai, M.T. / Huang, Q. / Lineberger, J. ...Coburn, C.A. / Stachel, S.J. / Jones, K.G. / Steele, T.G. / Rush, D.M. / DiMuzio, J. / Pietrak, B.L. / Lai, M.T. / Huang, Q. / Lineberger, J. / Jin, L. / Munshi, S. / Holloway, K.M. / Espeseth, A. / Simon, A. / Hazuda, D. / Graham, S.L. / Vacca, J.P.
External linksBioorg. Med. Chem. Lett. / PubMed:16690314
MethodsX-ray diffraction
Resolution1.8 Å
Structure data

PDB-2qzl:
Crystal Structure of human Beta Secretase complexed with IXS
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

Chemicals

ChemComp-IXS:
N-[(1S)-1-benzyl-2-{[(1S)-2-(isobutylamino)-1-methyl-2-oxoethyl]amino}ethyl]-N'-[(1R)-1-(4-fluorophenyl)ethyl]-5-[methyl(methylsulfonyl)amino]isophthalamide

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / ASPARTYL PROTEASE / BACE / Alternative splicing / Glycoprotein / Membrane / Transmembrane / Zymogen

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