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TitleDevelopment of sulfonamide compounds as potent methionine aminopeptidase type II inhibitors with antiproliferative properties.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 16, Page 3574-3577, Year 2006
Publish dateMar 7, 2006 (structure data deposition date)
AuthorsKawai, M. / BaMaung, N.Y. / Fidanze, S.D. / Erickson, S.A. / Tedrow, J.S. / Sanders, W.J. / Vasudevan, A. / Park, C. / Hutchins, C. / Comess, K.M. ...Kawai, M. / BaMaung, N.Y. / Fidanze, S.D. / Erickson, S.A. / Tedrow, J.S. / Sanders, W.J. / Vasudevan, A. / Park, C. / Hutchins, C. / Comess, K.M. / Kalvin, D. / Wang, J. / Zhang, Q. / Lou, P. / Tucker-Garcia, L. / Bouska, J. / Bell, R.L. / Lesniewski, R. / Henkin, J. / Sheppard, G.S.
External linksBioorg. Med. Chem. Lett. / PubMed:16632353
MethodsX-ray diffraction
Resolution1.95 Å
Structure data

PDB-2ga2:
h-MetAP2 complexed with A193400
Method: X-RAY DIFFRACTION / Resolution: 1.95 Å

Chemicals

ChemComp-MN:
Unknown entry

ChemComp-A19:
5-BROMO-2-{[(4-CHLOROPHENYL)SULFONYL]AMINO}BENZOIC ACID

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / complex

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