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Structure paper

TitleTransition-state Complex of the Purine-specific Nucleoside Hydrolase of T.vivax: Enzyme Conformational Changes and Implications for Catalysis.
Journal, issue, pagesJ. Mol. Biol., Vol. 359, Page 331-346, Year 2006
Publish dateDec 18, 2005 (structure data deposition date)
AuthorsVersees, W. / Barlow, J. / Steyaert, J.
External linksJ. Mol. Biol. / PubMed:16630632
MethodsX-ray diffraction
Resolution2.07 - 2.2 Å
Structure data

PDB-2ff1:
Crystal structure of Trypanosoma vivax nucleoside hydrolase soaked with ImmucillinH
Method: X-RAY DIFFRACTION / Resolution: 2.07 Å

PDB-2ff2:
Crystal structure of Trypanosoma vivax nucleoside hydrolase co-crystallized with ImmucillinH
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

Chemicals

ChemComp-CA:
Unknown entry

ChemComp-IMH:
1,4-DIDEOXY-4-AZA-1-(S)-(9-DEAZAHYPOXANTHIN-9-YL)-D-RIBITOL

ChemComp-HOH:
WATER

ChemComp-NI:
NICKEL (II) ION

Source
  • trypanosoma vivax (eukaryote)
KeywordsHYDROLASE / Rossmann fold / disordered loops / aromatic stacking / loop ordering

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