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TitleMechanism of Drug Resistance Revealed by the Crystal Structure of the Unliganded HIV-1 Protease with F53L Mutation.
Journal, issue, pagesJ. Mol. Biol., Vol. 358, Page 1191-1199, Year 2006
Publish dateFeb 24, 2006 (structure data deposition date)
AuthorsLiu, F. / Kovalevsky, A.Y. / Louis, J.M. / Boross, P.I. / Wang, Y.F. / Harrison, R.W. / Weber, I.T.
External linksJ. Mol. Biol. / PubMed:16569415
MethodsX-ray diffraction
Resolution1.35 Å
Structure data

PDB-2g69:
Structure of Unliganded HIV-1 Protease F53L Mutant
Method: X-RAY DIFFRACTION / Resolution: 1.35 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • human immunodeficiency virus 1
KeywordsHYDROLASE / aspartic protease / catalysis / unliganded / flap mutant / non-active site mutant

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