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Structure paper

Title2'-Fluoroarabino- and arabinonucleic acid show different conformations, resulting in deviating RNA affinities and processing of their heteroduplexes with RNA by RNase H.
Journal, issue, pagesBiochemistry, Vol. 45, Page 4141-4152, Year 2006
Publish dateDec 29, 2005 (structure data deposition date)
AuthorsLi, F. / Sarkhel, S. / Wilds, C.J. / Wawrzak, Z. / Prakash, T.P. / Manoharan, M. / Egli, M.
External linksBiochemistry / PubMed:16566588
MethodsX-ray diffraction
Resolution1.13 - 1.69 Å
Structure data

PDB-2fih:
Crystal Structure Analysis of the B-DNA Dodecamer CGCGAA-aU-TCGCG, with Incorporated Arabino-Uridine (aU)
Method: X-RAY DIFFRACTION / Resolution: 1.13 Å

PDB-2fii:
Crystal Structure Analysis of the B-DNA Dodecamer CGCGAAT-aU-CGCG, with Incorporated Arabino-Uridin (aU)
Method: X-RAY DIFFRACTION / Resolution: 1.24 Å

PDB-2fij:
Crystal Structure Analysis of the A-DNA Decamer GCGT-2'OMeA-aU-ACGC, with Incorporated 2'-O-Methylated-Adenosine (2'OMeA) and Arabino-Uridine (aU)
Method: X-RAY DIFFRACTION / Resolution: 1.19 Å

PDB-2fil:
Crystal Structure Analysis of the A-DNA Decamer GCGT-2'OMeA-faT-ACGC, with Incorporated 2'-O-Methylated-Adenosine (2'OMeA) and 2'-Fluoroarabino-Thymidine (faT)
Method: X-RAY DIFFRACTION / Resolution: 1.69 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-CL:
Unknown entry

ChemComp-NCO:
COBALT HEXAMMINE(III)

KeywordsDNA / Arabinonucleic Acid / Sugar Modifications / B-form DNA / A-form DNA / 2'-Fluoroarabino Acid

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