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TitleSynthesis and SAR of 1,9-dihydro-9-hydroxypyrazolo[3,4-b]quinolin-4-ones as novel, selective c-Jun N-terminal kinase inhibitors.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 16, Page 2590-2594, Year 2006
Publish dateFeb 10, 2006 (structure data deposition date)
AuthorsLiu, M. / Xin, Z. / Clampit, J.E. / Wang, S. / Gum, R.J. / Haasch, D.L. / Trevillyan, J.M. / Abad-Zapatero, C. / Fry, E.H. / Sham, H.L. / Liu, G.
External linksBioorg. Med. Chem. Lett. / PubMed:16527482
MethodsX-ray diffraction
Resolution3.5 Å
Structure data

PDB-2g01:
Pyrazoloquinolones as Novel, Selective JNK1 inhibitors
Method: X-RAY DIFFRACTION / Resolution: 3.5 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-73Q:
6-CHLORO-9-HYDROXY-1,3-DIMETHYL-1,9-DIHYDRO-4H-PYRAZOLO[3,4-B]QUINOLIN-4-ONE

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / JNK1 / c-jun N-Terminal Kinase / Protein Kinase JNK1 inhibitors

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