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| Title | Discovery of S-[5-Amino-1-(4-fluorophenyl)-1H-pyrazol-4-yl]-[3-(2,3-dihydroxypropoxy)phenyl]-methanone (RO3201195), and Orally Bioavailable and Highly Selective Inhibitor of p38 Map Kinase |
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| Journal, issue, pages | J. Med. Chem., Vol. 49, Page 1562-1575, Year 2006 |
| Publish date | Mar 23, 2006 (structure data deposition date) |
 Authors | Goldstein, D.M. / Alfredson, T.A. / Bertrand, J. / Browner, M.F. / Clifford, K. / Dalrymple, S. / Dunn, J. / Freire-Moare, J. / Harris, S.F. / Labadie, S.S. ...Goldstein, D.M. / Alfredson, T.A. / Bertrand, J. / Browner, M.F. / Clifford, K. / Dalrymple, S. / Dunn, J. / Freire-Moare, J. / Harris, S.F. / Labadie, S.S. / La Fargue, J. / Lapierre, J.M. / Larrabee, S. / Li, F. / Papp, E. / McWeeney, D. / Ramesha, C. / Roberts, R. / Rotstein, D. / San Pablo, B. / Sjogren, E. / So, O.Y. / Talamas, F.X. / Tao, W. / Trejo, A. / Villasenor, A. / Welch, M. / Welch, T. / Weller, P. / Whiteley, P.E. / Young, K. / Zipfel, S. |
 External links | J. Med. Chem. / PubMed:16509574 |
| Methods | X-ray diffraction |
| Resolution | 1.752 Å |
| Structure data |  PDB-2gfs: |
| Chemicals |  ChemComp-PQB:  ChemComp-HOH: |
| Source |
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 Keywords | SIGNALING PROTEIN / TRANSFERASE / P38; MAP KINASE; SERINE/THREONINE KINASE |
homo sapiens (human)