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Structure paper

TitleSAR and Mode of Action of Novel Non-Nucleoside Inhibitors of Hepatitis C NS5b RNA Polymerase.
Journal, issue, pagesJ. Med. Chem., Vol. 49, Page 1034-1046, Year 2006
Publish dateSep 2, 2005 (structure data deposition date)
AuthorsPowers, J.P. / Piper, D.E. / Li, Y. / Mayorga, V. / Anzola, J. / Chen, J.M. / Jaen, J.C. / Lee, G. / Liu, J. / Peterson, M.G. ...Powers, J.P. / Piper, D.E. / Li, Y. / Mayorga, V. / Anzola, J. / Chen, J.M. / Jaen, J.C. / Lee, G. / Liu, J. / Peterson, M.G. / Tonn, G.R. / Ye, Q. / Walker, N.P. / Wang, Z.
External linksJ. Med. Chem. / PubMed:16451069
MethodsX-ray diffraction
Resolution2 - 2.15 Å
Structure data

PDB-2awz:
Hepatitis C Virus NS5b RNA Polymerase in complex with a covalent inhibitor (5h)
Method: X-RAY DIFFRACTION / Resolution: 2.15 Å

PDB-2ax0:
Hepatitis C Virus NS5b RNA Polymerase in complex with a covalent inhibitor (5x)
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-2ax1:
Hepatitis C Virus NS5b RNA Polymerase in complex with a covalent inhibitor (5ee)
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-5H:
5R-(4-BROMOPHENYLMETHYL)-3-(BENZENESULFONYLAMINO)-4-OXO-2-THIONOTHIAZOLIDINE

ChemComp-HOH:
WATER

ChemComp-5X:
5R-(2E-METHYL-3-PHENYL-ALLYL)-3-(BENZENESULFONYLAMINO)-4-OXO-2-THIONOTHIAZOLIDINE

ChemComp-5EE:
5R-(3,4-DICHLOROPHENYLMETHYL)-3-(2-THIOPHENESULFONYLAMINO)-4-OXO-2-THIONOTHIAZOLIDINE

Source
  • hepatitis c virus
KeywordsTRANSFERASE / HCV / NS5B / Polymerase / Fingers / Thumb / Palm

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