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Title | Kinesin spindle protein (KSP) inhibitors. Part 2: the design, synthesis, and characterization of 2,4-diaryl-2,5-dihydropyrrole inhibitors of the mitotic kinesin KSP. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 16, Page 1775-1779, Year 2006 |
Publish date | Jan 5, 2006 (structure data deposition date) |
Authors | Fraley, M.E. / Garbaccio, R.M. / Arrington, K.L. / Hoffman, W.F. / Tasber, E.S. / Coleman, P.J. / Buser, C.A. / Walsh, E.S. / Hamilton, K. / Fernandes, C. ...Fraley, M.E. / Garbaccio, R.M. / Arrington, K.L. / Hoffman, W.F. / Tasber, E.S. / Coleman, P.J. / Buser, C.A. / Walsh, E.S. / Hamilton, K. / Fernandes, C. / Schaber, M.D. / Lobell, R.B. / Tao, W. / South, V.J. / Yan, Y. / Kuo, L.C. / Prueksaritanont, T. / Shu, C. / Torrent, M. / Heimbrook, D.C. / Kohl, N.E. / Huber, H.E. / Hartman, G.D. |
External links | Bioorg. Med. Chem. Lett. / PubMed:16439123 |
Methods | X-ray diffraction |
Resolution | 2.3 - 2.5 Å |
Structure data | PDB-2fky: PDB-2fl2: PDB-2fl6: |
Chemicals | ChemComp-MG: ChemComp-ADP: ChemComp-N2T: ChemComp-HOH: ChemComp-N4T: ChemComp-N5T: |
Source |
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Keywords | CELL CYCLE / KSP / KSP-inhibitor complex |