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Structure paper

Title2.0 angstroms structure of prostaglandin H2 synthase-1 reconstituted with a manganese porphyrin cofactor.
Journal, issue, pagesActa Crystallogr. ,Sect. D, Vol. 62, Page 151-156, Year 2006
Publish dateSep 7, 2005 (structure data deposition date)
AuthorsGupta, K. / Selinsky, B.S. / Loll, P.J.
External linksActa Crystallogr. ,Sect. D / PubMed:16421446
MethodsX-ray diffraction
Resolution2 Å
Structure data

PDB-2ayl:
2.0 Angstrom Crystal Structure of Manganese Protoporphyrin IX-reconstituted Ovine Prostaglandin H2 Synthase-1 Complexed With Flurbiprofen
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-BOG:
octyl beta-D-glucopyranoside / detergent*YM

ChemComp-FLP:
FLURBIPROFEN / antiinflammatory*YM

ChemComp-MNH:
MANGANESE PROTOPORPHYRIN IX

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • ovis aries (sheep)
KeywordsOXIDOREDUCTASE / cyclooxygenase / non-steroidal anti-inflammatory drug / peroxidase / prostaglandin synthase / egf-like domain / membrane binding domain / maganese protoporphyrin IX

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