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Structure paper

TitleMapping the structure and function of the E1 and E2 glycoproteins in alphaviruses.
Journal, issue, pagesStructure, Vol. 14, Issue 1, Page 63-73, Year 2006
Publish dateJan 12, 2006
AuthorsSuchetana Mukhopadhyay / Wei Zhang / Stefan Gabler / Paul R Chipman / Ellen G Strauss / James H Strauss / Timothy S Baker / Richard J Kuhn / Michael G Rossmann
External linksPubMed:16407066 / Publisher's page
MethodsEM (single particle, icos. sym.) / EM (single particle)
Resolution9 A
Structure data

EMDB-1121:
Mapping the structure and function of the E1 and E2 glycoproteins in alphaviruses.

PDB-1z8y:
Mapping the E2 Glycoprotein of Alphaviruses

SourceSindbis virus / virus / シンドビスウイルス
sindbis virus / virus
KeywordsCryoelectron Microscopy / Crystallography, X-Ray / Membrane Glycoproteins / Nucleocapsid Proteins / Protein Interaction Mapping / Protein Structure, Tertiary / Sindbis Virus / Viral Envelope Proteins / Viral Fusion Proteins / glycoprotein E1, Sindbis virus / glycoprotein E2, Sindbis virus / VIRUS / icosahedral enveloped virus / Icosahedral virus / Virus

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Three pioneers of this field were awarded Nobel Prize in Chemistry 2017

  • Jacques Dubochet (University of Lausanne, Switzerland) is a pioneer of ice-embedding method of EM specimen (as known as cryo-EM), Most of 3DEM structures in EMDB and PDB are obtained using his method.
  • Joachim Frank (Columbia University, New York, USA) is a pioneer of single particle reconstruction, which is the most used reconstruction method for 3DEM structures in EMDB and EM entries in PDB. And also, he is a develper of Spider, which is one of the most famous software in this field, and is used for some EM Navigor data (e.g. map projection/slice images).
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External links: The 2017 Nobel Prize in Chemistry - Press Release

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