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| Title | Discovery of trans-3,4'-bispyridinylethylenes as potent and novel inhibitors of protein kinase B (PKB/Akt) for the treatment of cancer: Synthesis and biological evaluation. |
|---|---|
| Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 16, Page 1679-1685, Year 2006 |
| Publish date | Dec 1, 2005 (structure data deposition date) |
Authors | Li, Q. / Li, T. / Zhu, G.D. / Gong, J. / Claibone, A. / Dalton, C. / Luo, Y. / Johnson, E.F. / Shi, Y. / Liu, X. ...Li, Q. / Li, T. / Zhu, G.D. / Gong, J. / Claibone, A. / Dalton, C. / Luo, Y. / Johnson, E.F. / Shi, Y. / Liu, X. / Klinghofer, V. / Bauch, J.L. / Marsh, K.C. / Bouska, J.J. / Arries, S. / De Jong, R. / Oltersdorf, T. / Stoll, V.S. / Jakob, C.G. / Rosenberg, S.H. / Giranda, V.L. |
External links | Bioorg. Med. Chem. Lett. / PubMed:16403626 |
| Methods | X-ray diffraction |
| Resolution | 1.9 Å |
| Structure data | ![]() PDB-2f7x: |
| Chemicals | ![]() ChemComp-4EA: ![]() ChemComp-HOH: |
| Source |
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Keywords | TRANSFERASE / Protein Kinase A / AKT inhibitors |
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