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Structure paper

TitleStructure of microsomal cytochrome P450 2B4 complexed with the antifungal drug bifonazole: insight into P450 conformational plasticity and membrane interaction.
Journal, issue, pagesJ. Biol. Chem., Vol. 281, Page 5973-5981, Year 2006
Publish dateOct 20, 2005 (structure data deposition date)
AuthorsZhao, Y. / White, M.A. / Muralidhara, B.K. / Sun, L. / Halpert, J.R. / Stout, C.D.
External linksJ. Biol. Chem. / PubMed:16373351
MethodsX-ray diffraction
Resolution2.3 Å
Structure data

PDB-2bdm:
Structure of Cytochrome P450 2B4 with Bound Bifonazole
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-HEM:
PROTOPORPHYRIN IX CONTAINING FE

ChemComp-TMI:
1-[PHENYL-(4-PHENYLPHENYL)-METHYL]IMIDAZOLE / antifungal*YM

ChemComp-CM5:
5-CYCLOHEXYL-1-PENTYL-BETA-D-MALTOSIDE / detergent*YM

ChemComp-HOH:
WATER

Source
  • oryctolagus cuniculus (rabbit)
KeywordsOXIDOREDUCTASE / p450 / Monooxygenase / membrane protein / CYP 2B4 / CYP LM2

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