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-Structure paper
Title | Mutations conferring resistance to SCH6, a novel hepatitis C virus NS3/4A protease inhibitor. Reduced RNA replication fitness and partial rescue by second-site mutations |
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Journal, issue, pages | J. Biol. Chem., Vol. 281, Page 8205-8215, Year 2006 |
Publish date | Jan 6, 2006 (structure data deposition date) |
![]() | Yi, M. / Tong, X. / Skelton, A. / Chase, R. / Chen, T. / Prongay, A. / Bogen, S.L. / Saksena, A.K. / Njoroge, F.G. / Veselenak, R.L. ...Yi, M. / Tong, X. / Skelton, A. / Chase, R. / Chen, T. / Prongay, A. / Bogen, S.L. / Saksena, A.K. / Njoroge, F.G. / Veselenak, R.L. / Pyles, R.B. / Bourne, N. / Malcolm, B.A. / Lemon, S.M. |
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Methods | X-ray diffraction |
Resolution | 2.7 Å |
Structure data | ![]() PDB-2fm2: |
Chemicals | ![]() ChemComp-ZN: ![]() ChemComp-BME: ![]() ChemComp-3BC: ![]() ChemComp-HOH: |
Source |
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![]() | HYDROLASE / Hepatitis C Virus / HCV / NS3/4A protease / ketoamide inhibitor |