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Structure paper

TitleThe Crystal Structure of TrpD, a Metabolic Enzyme Essential for Lung Colonization by Mycobacterium tuberculosis, in Complex with its Substrate Phosphoribosylpyrophosphate.
Journal, issue, pagesJ. Mol. Biol., Vol. 355, Page 784-797, Year 2006
Publish dateJun 2, 2005 (structure data deposition date)
AuthorsLee, C.E. / Goodfellow, C. / Javid-Majd, F. / Baker, E.N. / Lott, J.S.
External linksJ. Mol. Biol. / PubMed:16337227
MethodsX-ray diffraction
Resolution1.9 - 2.3 Å
Structure data

PDB-1zvw:
The Crystal Structure of TrpD (Rv2192c) from Mycobacterium tuberculosis in Complex with PRPP and Magnesium
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-2bpq:
Anthranilate phosphoribosyltransferase (TrpD) from Mycobacterium tuberculosis (Apo structure)
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-PRP:
1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose

ChemComp-BEN:
BENZAMIDINE

ChemComp-HOH:
WATER

ChemComp-GOL:
GLYCEROL

Source
  • mycobacterium tuberculosis (bacteria)
KeywordsTRANSFERASE / anthranilate phosphoribosyl transferase / Structural Genomics / PSI / Protein Structure Initiative / Mycobacterium Tuberculosis Structural Proteomics Project / TB Structural Genomics Consortium / TBSGC / TRYPTOPHAN BIOSYNTHESIS / ANTHRANILATE / TRANSFERASE PHOSPHORIBOSYLTRANSFERASE / AMINO-ACID BIOSYNTHESIS / AROMATIC AMINO ACID BIOSYNTHESIS / GLYCOSYLTRANSFERASE

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