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TitleCrystal structure of the hypoxia-inducible form of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB3): a possible new target for cancer therapy.
Journal, issue, pagesJ. Biol. Chem., Vol. 281, Page 2939-2944, Year 2006
Publish dateSep 5, 2005 (structure data deposition date)
AuthorsKim, S.G. / Manes, N.P. / El-Maghrabi, M.R. / Lee, Y.H.
External linksJ. Biol. Chem. / PubMed:16316985
MethodsX-ray diffraction
Resolution2.1 Å
Structure data

PDB-2axn:
Crystal structure of the human inducible form 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

Chemicals

ChemComp-F6P:
6-O-phosphono-beta-D-fructofuranose

ChemComp-EDT:
{[-(BIS-CARBOXYMETHYL-AMINO)-ETHYL]-CARBOXYMETHYL-AMINO}-ACETIC ACID

ChemComp-ADP:
ADENOSINE-5'-DIPHOSPHATE / ADP, energy-carrying molecule*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / HYDROLASE / bifunctional enzyme / EDTA complex

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