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TitleStructural, mutagenic, and kinetic analysis of the binding of substrates and inhibitors of human phenylethanolamine N-methyltransferase
Journal, issue, pagesJ. Med. Chem., Vol. 48, Page 7243-7252, Year 2005
Publish dateFeb 27, 2005 (structure data deposition date)
AuthorsWu, Q. / Gee, C.L. / Lin, F. / Tyndall, J.D. / Martin, J.L. / Grunewald, G.L. / McLeish, M.J.
External linksJ. Med. Chem. / PubMed:16279783
MethodsX-ray diffraction
Resolution2.4 Å
Structure data

PDB-1yz3:
Structure of human pnmt complexed with cofactor product adohcy and inhibitor SK&F 64139
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

Chemicals

ChemComp-SKA:
7,8-DICHLORO-1,2,3,4-TETRAHYDROISOQUINOLINE

ChemComp-SAH:
S-ADENOSYL-L-HOMOCYSTEINE

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / enzyme / product / inhibitor complex

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