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TitleCrystal structure of the complex of group I PLA2 with a group II-specific peptide Leu-Ala-Ile-Tyr-Ser (LAIYS) at 2.6 A resolution.
Journal, issue, pagesJ. Drug Target., Vol. 13, Page 367-374, Year 2005
Publish dateApr 25, 2004 (structure data deposition date)
AuthorsSingh, R.K. / Singh, N. / Jabeen, T. / Sharma, S. / Dey, S. / Singh, T.P.
External linksJ. Drug Target. / PubMed:16278156
MethodsX-ray diffraction
Resolution2.6 Å
Structure data

PDB-1t37:
Design of specific inhibitors of phospholipase A2: Crystal structure of the complex formed between group I phospholipase A2 and a designed pentapeptide Leu-Ala-Ile-Tyr-Ser at 2.6A resolution
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

PDB-1zm6:
Crystal structure of the complex formed beween a group I phospholipase A2 and designed penta peptide Leu-Ala-Ile-Tyr-Ser at 2.6A resolution
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

Chemicals

ChemComp-ACT:
ACETATE ION

ChemComp-HOH:
WATER

Source
  • naja sagittifera (cobra)
KeywordsHYDROLASE / Phospholipase A2 / complex / Inhibition / peptide design / inhibitor

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