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TitleMolecular basis for the glyphosate-insensitivity of the reaction of 5-enolpyruvylshikimate 3-phosphate synthase with shikimate.
Journal, issue, pagesFebs Lett., Vol. 579, Page 5773-5780, Year 2005
Publish dateJul 13, 2005 (structure data deposition date)
AuthorsPriestman, M.A. / Healy, M.L. / Funke, T. / Becker, A. / Schonbrunn, E.
External linksFebs Lett. / PubMed:16225867
MethodsX-ray diffraction
Resolution1.5 - 1.55 Å
Structure data

PDB-2aa9:
EPSP synthase liganded with shikimate
Method: X-RAY DIFFRACTION / Resolution: 1.5 Å

PDB-2aay:
EPSP synthase liganded with shikimate and glyphosate
Method: X-RAY DIFFRACTION / Resolution: 1.55 Å

Chemicals

ChemComp-SKM:
(3R,4S,5R)-3,4,5-TRIHYDROXYCYCLOHEX-1-ENE-1-CARBOXYLIC ACID

ChemComp-FMT:
FORMIC ACID

ChemComp-HOH:
WATER

ChemComp-GPJ:
GLYPHOSATE

Source
  • escherichia coli (E. coli)
KeywordsTRANSFERASE / inside-out alpha/beta barrel

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