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TitleThe structural basis of Janus kinase 2 inhibition by a potent and specific pan-Janus kinase inhibitor.
Journal, issue, pagesBlood, Vol. 107, Page 176-183, Year 2006
Publish dateOct 4, 2005 (structure data deposition date)
AuthorsLucet, I.S. / Fantino, E. / Styles, M. / Bamert, R. / Patel, O. / Broughton, S.E. / Walter, M. / Burns, C.J. / Treutlein, H. / Wilks, A.F. / Rossjohn, J.
External linksBlood / PubMed:16174768
MethodsX-ray diffraction
Resolution2 Å
Structure data

PDB-2b7a:
The structural basis of Janus Kinase 2 inhibition by a potent and specific pan-Janus kinase inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-IZA:
2-TERT-BUTYL-9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLINE-7-ONE

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / Kinase

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