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Structure paper

TitleIdentification of a selective ERK inhibitor and structural determination of the inhibitor-ERK2 complex
Journal, issue, pagesBiochem. Biophys. Res. Commun., Vol. 336, Page 357-363, Year 2005
Publish dateJun 30, 2004 (structure data deposition date)
AuthorsOhori, M. / Kinoshita, T. / Okubo, M. / Sato, K. / Yamazaki, A. / Arakawa, H. / Nishimura, S. / Inamura, N. / Nakajima, H. / Neya, M. ...Ohori, M. / Kinoshita, T. / Okubo, M. / Sato, K. / Yamazaki, A. / Arakawa, H. / Nishimura, S. / Inamura, N. / Nakajima, H. / Neya, M. / Miyake, H. / Fujii, T.
External linksBiochem. Biophys. Res. Commun. / PubMed:16139248
MethodsX-ray diffraction
Resolution2.5 Å
Structure data

PDB-1tvo:
The structure of ERK2 in complex with a small molecule inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

Chemicals

ChemComp-FRZ:
5-(2-PHENYLPYRAZOLO[1,5-A]PYRIDIN-3-YL)-1H-PYRAZOLO[3,4-C]PYRIDAZIN-3-AMINE

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / KINASE / PROTEIN-INHIBITOR COMPLEX

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