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Title | Probing the Subpockets of Factor Xa Reveals Two Binding Modes for Inhibitors Based on a 2-Carboxyindole Scaffold: A Study Combining Structure-Activity Relationship and X-Ray Crystallography. |
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Journal, issue, pages | J. Med. Chem., Vol. 48, Page 4511-, Year 2005 |
Publish date | Apr 11, 2005 (structure data deposition date) |
Authors | Nazare, M. / Will, D.W. / Matter, H. / Schreuder, H. / Ritter, K. / Urmann, M. / Essrich, M. / Bauer, A. / Wagner, M. / Czech, J. ...Nazare, M. / Will, D.W. / Matter, H. / Schreuder, H. / Ritter, K. / Urmann, M. / Essrich, M. / Bauer, A. / Wagner, M. / Czech, J. / Lorenz, M. / Laux, V. / Wehner, V. |
External links | J. Med. Chem. / PubMed:15999990 |
Methods | X-ray diffraction |
Resolution | 2.2 - 3 Å |
Structure data | PDB-2boh: PDB-2bq6: PDB-2bq7: PDB-2bqw: |
Chemicals | ChemComp-CA: ChemComp-IIA: ChemComp-HOH: ChemComp-IIB: ChemComp-IID: ChemComp-IIE: |
Source |
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Keywords | HYDROLASE/INHIBITOR / COMPLEX (HYDROLASE-INHIBITOR) / PROTEIN-INHIBITOR COMPLEX / BLOOD COAGULATION FACTOR / SERINE PROTEINASE / RATIONAL DRUG DESIGN / CALCIUM-BINDING / EGF-LIKE DOMAIN / GAMMA-CARBOXYGLUTAMIC ACID / GLYCOPROTEIN / HYDROLASE / HYDROXYLATION / PLASMA / POLYMORPHISM / PROTEASE / SERINE PROTEASE / VITAMIN K / ZYMOGEN / HYDROLASE-INHIBITOR COMPLEX / BLOOD COAGULATION / PROTEIN INHIBITOR COMPLEX |