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Structure paper

TitleStructural basis for the regulation of tubulin by vinblastine.
Journal, issue, pagesNature, Vol. 435, Page 519-522, Year 2005
Publish dateMar 8, 2005 (structure data deposition date)
AuthorsGigant, B. / Wang, C. / Ravelli, R.B. / Roussi, F. / Steinmetz, M.O. / Curmi, P.A. / Sobel, A. / Knossow, M.
External linksNature / PubMed:15917812
MethodsX-ray diffraction
Resolution4.1 Å
Structure data

PDB-1z2b:
Tubulin-colchicine-vinblastine: stathmin-like domain complex
Method: X-RAY DIFFRACTION / Resolution: 4.1 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-GTP:
GUANOSINE-5'-TRIPHOSPHATE / GTP, energy-carrying molecule*YM

ChemComp-GDP:
GUANOSINE-5'-DIPHOSPHATE / GDP, energy-carrying molecule*YM

ChemComp-CN2:
2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE

ChemComp-VLB:
(2ALPHA,2'BETA,3BETA,4ALPHA,5BETA)-VINCALEUKOBLASTINE / medication, chemotherapy*YM

Source
  • rattus norvegicus (Norway rat)
  • bos taurus (domestic cattle)
KeywordsCELL CYCLE / ALPHA-TUBULIN / BETA-TUBULIN / COLCHICINE / GTPASE / MICROTUBULE / STATHMIN / TUBULIN / VINBLASTINE

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