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Structure paper

TitleCrystal structure of a mutant mineralocorticoid receptor responsible for hypertension
Journal, issue, pagesNat. Struct. Mol. Biol., Vol. 12, Page 554-555, Year 2005
Publish dateDec 16, 2004 (structure data deposition date)
AuthorsFagart, J. / Huyet, J. / Pinon, G.M. / Rochel, M. / Mayer, C. / Rafestin-Oblin, M.E.
External linksNat. Struct. Mol. Biol. / PubMed:15908963
MethodsX-ray diffraction
Resolution1.96 - 2.34 Å
Structure data

PDB-1y9r:
Crystal structure of the human mineralocorticoid receptor ligand-binding domain bound to deoxycorticosterone and harboring the S810L mutation responsible for a severe form of hypertension
Method: X-RAY DIFFRACTION / Resolution: 1.96 Å

PDB-1ya3:
Crystal structure of the human mineralocorticoid receptor ligand-binding domain bound to progesterone and harboring the S810L mutation responsible for a severe form of hypertension
Method: X-RAY DIFFRACTION / Resolution: 2.34 Å

Chemicals

ChemComp-1CA:
DESOXYCORTICOSTERONE / hormone*YM

ChemComp-HOH:
WATER

ChemComp-STR:
PROGESTERONE / hormone*YM

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION / LIGAND BINDING PROTEIN / MINERALOCORTICOID RECEPTOR; STEROID RECEPTOR; NUCLEAR RECEPT; TRANSCRIPTION REGULATION; ACTIVATING MUTATION; HYPERTENSION / MINERALOCORTICOID RECEPTOR / STEROID RECEPTOR / NUCLEAR RECEPTOR TRANSCRIPTION REGULATION / ACTIVATING MUTATION / HYPERTENSION

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