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TitleAcyclic cyanamide-based inhibitors of cathepsin K.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 15, Page 3039-3043, Year 2005
Publish dateJan 17, 2005 (structure data deposition date)
AuthorsBarrett, D.G. / Deaton, D.N. / Hassell, A.M. / McFadyen, R.B. / Miller, A.B. / Miller, L.R. / Payne, J.A. / Shewchuk, L.M. / Willard, D.H. / Wright, L.L.
External linksBioorg. Med. Chem. Lett. / PubMed:15896958
MethodsX-ray diffraction
Resolution2.6 Å
Structure data

PDB-1yk8:
Cathepsin K complexed with a cyanamide-based inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

Chemicals

ChemComp-T2M:
TERT-BUTYL 2-CYANO-2-METHYLHYDRAZINECARBOXYLATE

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / catK / cathepsin / cysteine / protease

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