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Structure paper

TitleStructural basis for an unexpected mode of SERM-mediated ER antagonism.
Journal, issue, pagesMol. Cell, Vol. 18, Page 413-424, Year 2005
Publish dateOct 10, 2003 (structure data deposition date)
AuthorsWu, Y.L. / Yang, X. / Ren, Z. / McDonnell, D.P. / Norris, J.D. / Willson, T.M. / Greene, G.L.
External linksMol. Cell / PubMed:15893725
MethodsX-ray diffraction
Resolution2.7 Å
Structure data

PDB-1r5k:
Human Estrogen Receptor alpha Ligand-Binding Domain In Complex With GW5638
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

Chemicals

ChemComp-GW5:
(2E)-3-{4-[(1E)-1,2-DIPHENYLBUT-1-ENYL]PHENYL}ACRYLIC ACID / inhibitor*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsDNA BINDING PROTEIN / Alpha helix / helical sandwich

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