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TitleScorpion-toxin mimics of CD4 in complex with human immunodeficiency virus gp120 crystal structures, molecular mimicry, and neutralization breadth.
Journal, issue, pagesStructure, Vol. 13, Page 755-768, Year 2005
Publish dateFeb 25, 2005 (structure data deposition date)
AuthorsHuang, C.C. / Stricher, F. / Martin, L. / Decker, J.M. / Majeed, S. / Barthe, P. / Hendrickson, W.A. / Robinson, J. / Roumestand, C. / Sodroski, J. ...Huang, C.C. / Stricher, F. / Martin, L. / Decker, J.M. / Majeed, S. / Barthe, P. / Hendrickson, W.A. / Robinson, J. / Roumestand, C. / Sodroski, J. / Wyatt, R. / Shaw, G.M. / Vita, C. / Kwong, P.D.
External linksStructure / PubMed:15893666
MethodsX-ray diffraction
Resolution2.2 - 2.75 Å
Structure data

PDB-1yyl:
crystal structure of CD4M33, a scorpion-toxin mimic of CD4, in complex with HIV-1 YU2 gp120 envelope glycoprotein and anti-HIV-1 antibody 17b
Method: X-RAY DIFFRACTION / Resolution: 2.75 Å

PDB-1yym:
crystal structure of F23, a scorpion-toxin mimic of CD4, in complex with HIV-1 YU2 gp120 envelope glycoprotein and anti-HIV-1 antibody 17b
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-HOH:
WATER

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-IPA:
ISOPROPYL ALCOHOL / alkaloid*YM

Source
  • human immunodeficiency virus 1
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsViral protein/Immune system / HIV-1 / gp120 / YU2 / scorpion toxin / CD4 mimic / CD4M33 / antibody / Viral protein-Immune system COMPLEX / F23

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