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TitleCrystal Structure of Murine 11-Hydroxysteroid Dehydrogenase 1: An Important Therapeutic Target for Diabetes
Journal, issue, pagesBiochemistry, Vol. 44, Page 6948-6957, Year 2005
Publish dateDec 2, 2004 (structure data deposition date)
AuthorsZhang, J. / Osslund, T.D. / Plant, M.H. / Clogston, C.L. / Nybo, R.E. / Xiong, F. / Delaney, J.M. / Jordan, S.R.
External linksBiochemistry / PubMed:15865440
MethodsX-ray diffraction
Resolution2.3 - 3 Å
Structure data

PDB-1y5m:
The crystal structure of murine 11b-hydroxysteroid dehydrogenase: an important therapeutic target for diabetes
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-1y5r:
The crystal structure of murine 11b-hydroxysteroid dehydrogenase complexed with corticosterone
Method: X-RAY DIFFRACTION / Resolution: 3 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-NDP:
NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE

ChemComp-OCT:
N-OCTANE

ChemComp-HOH:
WATER

ChemComp-C0R:
CORTICOSTERONE / hormone*YM

Source
  • mus musculus (house mouse)
KeywordsOXIDOREDUCTASE / ROSSMANN FOLD / corticosterone bound

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