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TitleDiscovery of 3-[(4,5,7-trifluorobenzothiazol-2-yl)methyl]indole-N-acetic acid (lidorestat) and congeners as highly potent and selective inhibitors of aldose reductase for treatment of chronic diabetic complications
Journal, issue, pagesJ. Med. Chem., Vol. 48, Page 3141-3152, Year 2005
Publish dateMar 14, 2005 (structure data deposition date)
AuthorsVan Zandt, M.C. / Jones, M.L. / Gunn, D.E. / Geraci, L.S. / Jones, J.H. / Sawicki, D.R. / Sredy, J. / Jacot, J.L. / Dicioccio, A.T. / Petrova, T. ...Van Zandt, M.C. / Jones, M.L. / Gunn, D.E. / Geraci, L.S. / Jones, J.H. / Sawicki, D.R. / Sredy, J. / Jacot, J.L. / Dicioccio, A.T. / Petrova, T. / Mitschler, A. / Podjarny, A.D.
External linksJ. Med. Chem. / PubMed:15857120
MethodsX-ray diffraction
Resolution1.04 Å
Structure data

PDB-1z3n:
Human aldose reductase in complex with NADP+ and the inhibitor lidorestat at 1.04 angstrom
Method: X-RAY DIFFRACTION / Resolution: 1.04 Å

Chemicals

ChemComp-NDP:
NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE

ChemComp-3NA:
{3-[(4,5,7-TRIFLUORO-1,3-BENZOTHIAZOL-2-YL)METHYL]-1H-INDOL-1-YL}ACETIC ACID

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE / NADP+ / LIDORESTAT

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