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TitleDesign and synthesis of potent pyridazine inhibitors of p38 MAP kinase.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 15, Page 2409-2413, Year 2005
Publish dateFeb 1, 2005 (structure data deposition date)
AuthorsTamayo, N. / Liao, L. / Goldberg, M. / Powers, D. / Tudor, Y.Y. / Yu, V. / Wong, L.M. / Henkle, B. / Middleton, S. / Syed, R. ...Tamayo, N. / Liao, L. / Goldberg, M. / Powers, D. / Tudor, Y.Y. / Yu, V. / Wong, L.M. / Henkle, B. / Middleton, S. / Syed, R. / Harvey, T. / Jang, G. / Hungate, R. / Dominguez, C.
External linksBioorg. Med. Chem. Lett. / PubMed:15837335
MethodsX-ray diffraction
Resolution2 Å
Structure data

PDB-1yqj:
Crystal Structure of p38 Alpha in Complex with a Selective Pyridazine Inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-6NP:
6((S)-3-BENZYLPIPERAZIN-1-YL)-3-(NAPHTHALEN-2-YL)-4-(PYRIDIN-4-YL)PYRAZINE

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE

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