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TitleOximinoarylsulfonamides as potent HIV protease inhibitors.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 15, Page 2275-2278, Year 2005
Publish dateFeb 10, 2005 (structure data deposition date)
AuthorsYeung, C.M. / Klein, L.L. / Flentge, C.A. / Randolph, J.T. / Zhao, C. / Sun, M. / Dekhtyar, T. / Stoll, V.S. / Kempf, D.J.
External linksBioorg. Med. Chem. Lett. / PubMed:15837308
MethodsX-ray diffraction
Resolution3 Å
Structure data

PDB-1yt9:
HIV Protease with oximinoarylsulfonamide bound
Method: X-RAY DIFFRACTION / Resolution: 3 Å

Chemicals

ChemComp-OIS:
(S)-N-((2S,3R)-3-HYDROXY-4-(4-((E)-(HYDROXYIMINO)METHYL)-N-ISOBUTYLPHENYLSULFONAMIDO)-1-PHENYLBUTAN-2-YL)-3-METHYL-2-(3

Source
  • human immunodeficiency virus 1
KeywordsHYDROLASE / HIV protease / oximinoarylsulfonamides

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