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TitleStructural basis for antagonism and resistance of bicalutamide in prostate cancer.
Journal, issue, pagesProc. Natl. Acad. Sci. Usa, Vol. 102, Page 6201-6206, Year 2005
Publish dateMar 31, 2005 (structure data deposition date)
AuthorsBohl, C.E. / Gao, W. / Miller, D.D. / Bell, C.E. / Dalton, J.T.
External linksProc. Natl. Acad. Sci. Usa / PubMed:15833816
MethodsX-ray diffraction
Resolution1.8 Å
Structure data

PDB-1z95:
Crystal Structure of the Androgen Receptor Ligand-binding Domain W741L Mutant Complex with R-bicalutamide
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-198:
R-BICALUTAMIDE / medication, hormone*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION REGULATION / RECEPTOR / steroid hormones; receptors; cellular proliferation; cellular differentiation

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