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-Structure paper
Title | Structure-based optimization of a non-beta-lactam lead results in inhibitors that do not up-regulate beta-lactamase expression in cell culture. |
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Journal, issue, pages | J. Am. Chem. Soc., Vol. 127, Page 4632-4639, Year 2005 |
Publish date | Sep 17, 2004 (structure data deposition date) |
Authors | Tondi, D. / Morandi, F. / Bonnet, R. / Costi, M.P. / Shoichet, B.K. |
External links | J. Am. Chem. Soc. / PubMed:15796528 |
Methods | X-ray diffraction |
Resolution | 1.96 - 1.97 Å |
Structure data | PDB-1xgi: PDB-1xgj: |
Chemicals | ChemComp-NST: ChemComp-HOH: ChemComp-HTC: |
Source |
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Keywords | HYDROLASE / AmpC / beta-lactamase / cephalosporinase / serine hydrolase |