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-Structure paper
Title | Mechanism of Sirtuin Inhibition by Nicotinamide: Altering the NAD(+) Cosubstrate Specificity of a Sir2 Enzyme. |
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Journal, issue, pages | Mol. Cell, Vol. 17, Page 855-868, Year 2005 |
Publish date | Dec 21, 2004 (structure data deposition date) |
![]() | Avalos, J.L. / Bever, K.M. / Wolberger, C. |
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Methods | X-ray diffraction |
Resolution | 1.4 - 2.4 Å |
Structure data | ![]() PDB-1yc2: ![]() PDB-1yc5: |
Chemicals | ![]() ChemComp-ZN: ![]() ChemComp-SO4: ![]() ChemComp-NAD: ![]() ChemComp-NCA: ![]() ChemComp-EDO: ![]() ChemComp-2PE: ![]() ChemComp-PG4: ![]() ChemComp-PGE: ![]() ChemComp-APR: ![]() ChemComp-HOH: |
Source |
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![]() | HYDROLASE / sir2 / sirtuin / nicotinamide / NAD / ADPribose / ternary complex / sir2Tm / SirT1 / p53 |