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TitleThe crystal structure of the complex of the anticancer prodrug 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin (CPT-11) with Torpedo californica acetylcholinesterase provides a molecular explanation for its cholinergic action
Journal, issue, pagesMol. Pharmacol., Vol. 67, Page 1874-1881, Year 2005
Publish dateJul 29, 2004 (structure data deposition date)
AuthorsHarel, M. / Hyatt, J.L. / Brumshtein, B. / Morton, C.L. / Yoon, K.J. / Wadkins, R.M. / Silman, I. / Sussman, J.L. / Potter, P.M.
External linksMol. Pharmacol. / PubMed:15772291
MethodsX-ray diffraction
Resolution2.61 Å
Structure data

PDB-1u65:
Ache W. CPT-11
Method: X-RAY DIFFRACTION / Resolution: 2.61 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-CP0:
(4S)-4,11-DIETHYL-4-HYDROXY-3,14-DIOXO-3,4,12,14-TETRAHYDRO-1H-PYRANO[3',4':6,7]INDOLIZINO[1,2-B]QUINOLIN-9-YL 1,4'-BIPIPERIDINE-1'-CARBOXYLATE / medication, anticancer*YM

ChemComp-IOD:
IODIDE ION

ChemComp-HOH:
WATER

Source
  • torpedo californica (Pacific electric ray)
KeywordsHYDROLASE / torpedo ache / anticancer prodrug CPT-11 / Israel Structural Proteomics Center / ISPC / Structural Genomics

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