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-Structure paper
Title | Discovery of 1-(3'-aminobenzisoxazol-5'-yl)-3-trifluoromethyl-N-[2-fluoro-4-[(2'-dimethylaminomethyl)imidazol-1-yl]phenyl]-1H-pyrazole-5-carboxyamide hydrochloride (razaxaban), a highly potent, selective, and orally bioavailable factor Xa inhibitor. |
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Journal, issue, pages | J. Med. Chem., Vol. 48, Page 1729-1744, Year 2005 |
Publish date | Mar 22, 2005 (structure data deposition date) |
Authors | Quan, M.L. / Lam, P.Y.S. / Han, Q. / Pinto, D.J.P. / He, M.Y. / Li, R. / Ellis, C.D. / Clark, C.G. / Teleha, C.A. / Sun, J.-H. ...Quan, M.L. / Lam, P.Y.S. / Han, Q. / Pinto, D.J.P. / He, M.Y. / Li, R. / Ellis, C.D. / Clark, C.G. / Teleha, C.A. / Sun, J.-H. / Alexander, R.S. / Bai, S. / Luettgen, J.M. / Knabb, R.M. / Wong, P.C. / Wexler, R.R. |
External links | J. Med. Chem. / PubMed:15771420 |
Methods | X-ray diffraction |
Resolution | 1.8 Å |
Structure data | PDB-1z6e: |
Chemicals | ChemComp-IK8: ChemComp-HOH: |
Source |
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Keywords | HYDROLASE / glycoprotein / serine protease / plasma / blood coagulation factor / protein inhibitor complex / calcium-binding / blood coagulation / cleavage on pair of basic residues / disulfide bond / egf-like domain |