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TitleDevelopment of alpha-keto-based inhibitors of cruzain, a cysteine protease implicated in Chagas disease
Journal, issue, pagesBioorg. Med. Chem., Vol. 13, Page 2141-2156, Year 2005
Publish dateAug 10, 2004 (structure data deposition date)
AuthorsChoe, Y. / Brinen, L.S. / Price, M.S. / Engel, J.C. / Lange, M. / Grisostomi, C. / Weston, S.G. / Pallai, P.V. / Cheng, H. / Hardy, L.W. ...Choe, Y. / Brinen, L.S. / Price, M.S. / Engel, J.C. / Lange, M. / Grisostomi, C. / Weston, S.G. / Pallai, P.V. / Cheng, H. / Hardy, L.W. / Hartsough, D.S. / McMakin, M. / Tilton, R.F. / Baldino, C.M. / Craik, C.S.
External linksBioorg. Med. Chem. / PubMed:15727867
MethodsX-ray diffraction
Resolution2.3 Å
Structure data

PDB-1u9q:
Crystal structure of cruzain bound to an alpha-ketoester
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-186:
[1-(1-METHYL-4,5-DIOXO-PENT-2-ENYLCARBAMOYL)-2-PHENYL-ETHYL]-CARBAMIC ACID BENZYL ESTER

ChemComp-HOH:
WATER

Source
  • trypanosoma cruzi (eukaryote)
KeywordsHYDROLASE / Clan-CA cysteine protease; covalent inhibitor

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