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Structure paper

TitleStructural and energetic consequences of mutations in a solvated hydrophobic cavity.
Journal, issue, pagesJ. Mol. Biol., Vol. 346, Page 307-318, Year 2005
Publish dateDec 31, 2003 (structure data deposition date)
AuthorsAdamek, D.H. / Guerrero, L. / Blaber, M. / Caspar, D.L.D.
External linksJ. Mol. Biol. / PubMed:15663946
MethodsX-ray diffraction
Resolution2.1 - 2.34 Å
Structure data

PDB-1s0l:
Interleukin 1 beta mutant F42W
Method: X-RAY DIFFRACTION / Resolution: 2.34 Å

PDB-1t4q:
Interleukin 1 beta F101W
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

PDB-1too:
Interleukin 1B Mutant F146W
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

PDB-1tp0:
Triple mutation in interleukin 1 beta cavity:replacement of phenylalanines with tryptophan.
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-1twe:
INTERLEUKIN 1 BETA MUTANT F101Y
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

PDB-1twm:
Interleukin-1 Beta Mutant F146Y
Method: X-RAY DIFFRACTION / Resolution: 2.26 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
Keywordsimmune response / cytokine / inflamatory response / pyrogen / IMMUNE SYSTEM / Hydration Cavity / il1b / IL-1b / Hydrophobic cavity / Hydrophobicity / water / solvation

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