EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Identification of Novel P38Alpha Map Kinase Inhibitors Using Fragment-Based Lead Generation
ジャーナル・号・ページ	J. Med. Chem., Vol. 48, Page 414-, Year 2005
掲載日	2004年9月16日 (構造データの登録日)
著者	Gill, A. / Frederickson, M. / Cleasby, A. / Woodhead, S. / Carr, M. / Woodhead, A. / Walker, M. / Congreve, M. / Devine, L. / Tisi, D. ...Gill, A. / Frederickson, M. / Cleasby, A. / Woodhead, S. / Carr, M. / Woodhead, A. / Walker, M. / Congreve, M. / Devine, L. / Tisi, D. / O'Reilly, M. / Seavers, L. / Davis, D. / Curry, J. / Anthony, R. / Padova, A. / Murray, C. / Carr, R. / Jhoti, H.
リンク	J. Med. Chem. / PubMed:15658855
手法	X線回折
解像度	1.8 - 2.5 Å
構造データ	PDB-1w82: p38 Kinase crystal structure in complex with small molecule inhibitor 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-1w83: p38 Kinase crystal structure in complex with small molecule inhibitor 手法: X-RAY DIFFRACTION / 解像度: 2.5 Å PDB-1w84: p38 Kinase crystal structure in complex with small molecule inhibitor 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-1wbn: fragment based p38 inhibitors 手法: X-RAY DIFFRACTION / 解像度: 2.4 Å PDB-1wbs: Identification of novel p38 alpha MAP Kinase inhibitors using fragment-based lead generation. 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-1wbt: Identification of novel p38 alpha MAP Kinase inhibitors using fragment-based lead generation. 手法: X-RAY DIFFRACTION / 解像度: 2 Å PDB-1wbv: Identification of novel p38 alpha MAP Kinase inhibitors using fragment-based lead generation. 手法: X-RAY DIFFRACTION / 解像度: 2 Å PDB-1wbw: Identification of novel p38 alpha MAP Kinase inhibitors using fragment-based lead generation. 手法: X-RAY DIFFRACTION / 解像度: 2.41 Å
化合物	ChemComp-L10: N-[(3Z)-5-TERT-BUTYL-2-PHENYL-1,2-DIHYDRO-3H-PYRAZOL-3-YLIDENE]-N'-(4-CHLOROPHENYL)UREA ChemComp-HOH: WATER ChemComp-L11: N-[4-CHLORO-3-(PYRIDIN-3-YLOXYMETHYL)-PHENYL]-3-FLUORO- ChemComp-L12: 3-(2-PYRIDIN-4-YLETHYL)-1H-INDOLE / 3-[2-(4-ピリジル)エチル]-1H-インド-ル ChemComp-L09: N-(3-TERT-BUTYL-1H-PYRAZOL-5-YL)-N'-{4-CHLORO-3-[(PYRIDIN-3-YLOXY)METHYL]PHENYL}UREA ChemComp-LI2: 3-FLUORO-5-MORPHOLIN-4-YL-N-[3-(2-PYRIDIN-4-YLETHYL)-1H-INDOL-5-YL]BENZAMIDE ChemComp-GOL: GLYCEROL / グリセロ-ル ChemComp-WBT: 3-FLUORO-5-MORPHOLIN-4-YL-N-[1-(2-PYRIDIN-4-YLETHYL)-1H-INDOL-6-YL]BENZAMIDE / N-[1-[2-(4-ピリジル)エチル]-1H-インド-ル-6-イル]-3-フルオロ-5-モルホリノベンズアミド ChemComp-LI3: 3-FLUORO-N-1H-INDOL-5-YL-5-MORPHOLIN-4-YLBENZAMIDE ChemComp-DMS: DIMETHYL SULFOXIDE / 2-チアプロパン2-オキシド / DMSO, 沈殿剤YM ChemComp-LI4*: 3-(1-NAPHTHYLMETHOXY)PYRIDIN-2-AMINE
由来	homo sapiens (ヒト)
キーワード	KINASE/INHIBITOR / KINASE-INHIBITOR COMPLEX / P38 / KINASE / INHIBITOR COMPLEX / TRANSFERASE / P38 MAP KINASE / INHIBITOR STRUCTURE / ALTERNATIVE SPLICING / ATP-BINDING / NUCLEAR PROTEIN / PHOSPHORYLATION / SERINE/THREONINE PROTEIN KINASE / MAP KINASE / SERINE/THREONINE-PROTEIN KINASE