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TitleA Structural Basis for Constitutive Activity in the Human CAR/RXRalpha Heterodimer.
Journal, issue, pagesMol. Cell, Vol. 16, Page 919-928, Year 2004
Publish dateOct 27, 2004 (structure data deposition date)
AuthorsXu, R.X. / Lambert, M.H. / Wisely, B.B. / Warren, E.N. / Weinert, E.E. / Waitt, G.M. / Williams, J.D. / Collins, J.L. / Moore, L.B. / Willson, T.M. / Moore, J.T.
External linksMol. Cell / PubMed:15610735
MethodsX-ray diffraction
Resolution2.6 - 2.7 Å
Structure data

PDB-1xv9:
crystal structure of CAR/RXR heterodimer bound with SRC1 peptide, fatty acid, and 5b-pregnane-3,20-dione.
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

PDB-1xvp:
crystal structure of CAR/RXR heterodimer bound with SRC1 peptide, fatty acid and CITCO
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

Chemicals

ChemComp-F15:
PENTADECANOIC ACID

ChemComp-CI2:
(5BETA)-PREGNANE-3,20-DIONE

ChemComp-HOH:
WATER

ChemComp-CID:
6-(4-CHLOROPHENYL)IMIDAZO[2,1-B][1,3]THIAZOLE-5-CARBALDEHYDE O-(3,4-DICHLOROBENZYL)OXIME

Source
  • homo sapiens (human)
KeywordsDNA BINDING PROTEIN / CAR / RXR / SRC1 / pregnanedione / CITCO

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